Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
Sodnom-Ish Buyanbileg, 어미영, 명훈, 이종호, 김성민,
소속 상세정보
( Sodnom-Ish Buyanbileg ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
어미영 ( Eo Mi-Young ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
명훈 ( Myoung Hoon ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이종호 ( Lee Jong-Ho ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.
키워드
Next generation sequencing; Saliva; Biomarkers; Early diagnosis; Oral squamous cell carcinoma
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